Clarendon County had had two incarnations - from 1785 to 1800, and from 1855 to the present day - both with essentially the same configuration at inception. In its first incarnation, Clarendon County ceded land for the creation of Salem County in 1792. In its second incarnation, Clarendon County ceded land for the creation of Florence County in 1888, and it ceded a small portion of land to Sumter County around 1922.

Its population was 2,392 in 1790. During its second incarnation, its population grew from 13,095 in 1860 to 32,502 in 2000. Click on the maps below to peruse the known towns and villages that came and went over two centuries - a few cannot be located since they do not show up on available maps of SC.