Authorized June 6, 1775 in the South Carolina State Troops as the 1st South Carolina Regiment. Organized in summer 1775 at Charleston to consist of ten companies from eastern South Carolina. Adopted November 4, 1775 into the Continental Army. Assigned February 27, 1776 to the Southern Department of the Continental Army.

Assigned November 23, 1776 to the 1st South Carolina Brigade, an element of the Southern Department. Relieved January 3, 1779 from the 1st South Carolina Brigade. Assigned February 1, 1779 to the South Carolina Brigade, an element of the Southern Department.

Consolidated February 11, 1780 with the 5th South Carolina Regiment [see 5th South Carolina Regiment] and the consolidated unit designated as the 1st South Carolina Regiment, an element of the South Carolina Brigade, to consist of nine companies. Captured May 12, 1780 at Charleston by the British Army.

Reorganized December 11, 1782 to March 19, 1783 at Charleston to consist of three companies. Furloughed May 1-14, 1783 at Charleston. Disbanded November 15, 1783.

Engagements:

Charleston 1775-1776
Florida 1778
Savannah
Charleston 1780

Captain Ioor's Company additionally served in the Caribbean in 1778.

1777 - Colonel Charles C. Pinckney led the regiment.