Authorized June 6, 1775 in the South Carolina State Troops as the 2nd South Carolina Regiment. Organized in summer 1775 at Charleston to consist of ten companies from eastern South Carolina. Adopted November 4, 1775 into the Continental Army. Assigned February 27, 1776 to the Southern Department.

Assigned November 23, 1776 to the 2nd South Carolina Brigade, an element of the Southern Department. Relieved August 26, 1778 from the 2nd South Carolina Brigade and assigned to the 1st South Carolina Brigade, an element of the Southern Department. Relieved January 3, 1779 from the 1st South Carolina Brigade. Assigned June 15, 1779 to McIntosh's Brigade, an element of the Southern Department. Relieved September 14, 1779 from McIntosh's Brigade and assigned to Huger's Brigade, an element of the Southern Department.

Consolidated February 11, 1780 with the 6th South Carolina Regiment [see 6th South Carolina Regiment] and consolidated unit designated as the 2nd South Carolina Regiment, to consist of nine companies; concurrently relieved from Huger's Brigade and assigned to the South Carolina Brigade, an element of the Southern Department.

Captured May 12, 1780 at Charleston by the British Army. Disbanded January 1, 1783.

Engagements:

Charleston 1775-1776
Savannah
Charleston 1780

Detachments additionally served in Florida.

* 1775, ten companies, 2nd SC Regiment
* Nov 1776, 2nd SC Brigade
* Aug 1778, 1st SC Brigade
* June 1779, McIntosh's Brigade
* Sept 1779, Huger's Brigade
* 1780 consolidated with 6th SC Regiment, 2nd SC Regiment, nine companies, SC Brigade; captured at Charleston.  

1777 - Colonel Isacc Motte led the regiment.