Found on some maps as Nelson's Ferry but named by the US Post Office Department as Neilsons Ferry, this town has the distinction of being the first (tied with Jacksonborough) hamlet in the old Charleston District to be granted a US Post Office on August 10, 1793, a full year and a half before the city and District Seat of Charleston received its first Post Office (2/16/1795).

A significant Revolutionary War battle was fought at Nelson's Ferry - so, perhaps this is why it received its PO so early after the war.

The first Postmaster was George Andrews. This Post Office was closed sometime prior to 1824, never to reopen. Its location was close to where the present-day town of Santee is in northwest Berkeley County, along the Santee River. Nelson's Ferry continued to show up on SC maps until around 1875. Not much more is known at this time.