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Authorized February 22, 1776 in the South Carolina Provincial Troops as the 5th South Carolina Regiment. Organized in spring 1776 at Charleston to consist of seven companies from eastern and northern South Carolina. Adopted March 25, 1776 into the Continental Army and assigned to the Southern Department.

Assigned November 23, 1776 to the 2nd South Carolina Brigade, an element of the Southern Department. Relieved January 3, 1779 from the 2nd South Carolina Brigade. Assigned February 1, 1779 to the South Carolina Brigade, an element of the Southern Department. Relieved May 1, 1779 from the South Carolina Brigade. Assigned June 15, 1779 to McIntosh's Brigade, an element of the Southern Department. Relieved September 14, 1779 from McIntosh's Brigade.

Consolidated February 11, 1780 with the 1st South Carolina Regiment [see 1st South Carolina Regiment].

Engagements:

Charleston 1775-1776
Savannah

Elements additionally served in Florida